Sustanon 250, 250mg ml solution for injection Summary of Product Characteristics SmPC emc
He had subsequent issues with elevated oestradiol and so Anastrozole (an aromatase inhibitor) was commenced to manage this. Disappointingly, after 15 months on Testosterone Undecanoate, alongside 300iu of HCG and 0.5mg of Anastrozole every 3.5 days, his trough level was still only 15.1nmol/l. This does not mean that it’s impossible to achieve stable levels with other Testosterone esters however. On the contrary, we have also experienced positive results with patients using Testosterone Undecanoate, the difference being that we use a more frequent microdose to achieve stability. He now has optimal male androgen levels – Total Testosterone 28.2nmol/l and Oestradiol 97pmol/l – all other biomarkers are healthy and he feels a subjective improvement in his overall sense of well-being.
- I have often lowered a patients self-perceived “optimal” levels, for them to report that their anxiety has settled and that their libidos have improved.
- Smaller injections are therefore warranted, and subcutaneous testosterone injections have become more common.
- That is understandable, since dealing with low testosterone is not often an easy feat.
- Different specialist centres have used doses varying from one injection of 1ml every two weeks to one injection of 1ml every four weeks.
- We want to reach a steady state to avoid large fluctuations in levels (although some leeway to mimic the natural diurnal pattern of Testosterone release is not a bad idea).
This shift, over time, can result in the hardening of the artery walls and higher levels of fat in the bloodstream leading to strokes, or heart attacks if left unchecked and untreated. Managing estrogenic side effects on testosterone propionate is usually done with Nolvadex at 10mg a day. The short ester and lower mg/ml dose mean there is less excess testosterone in the body to be aromatised.
Benefits of TRT
Though far from perfect, this generally leads to better outcomes than traditional NHS protocols. In female-to-male transsexuals, a single dose of Sustanon 250 repeated every two weeks resulted in mean trough testosterone levels towards the upper end of the normal male range at 2, 4 and 12 months. A single dose of Sustanon 250 leads to an increase of total plasma testosterone with peak levels of approximately 70nmol/l (Cmax), which are reached approximately h (tmax) after administration.
Our Research & Experience
It is not best for men with lower body fat levels but may be worth considering if you are rotating injection sites. It has been a fascinating, yet challenging journey to date, we look to the future with aspirations of changing practice. With that said, Gold Standard TRT is microdosing daily subcutaneous Testosterone Cypionate (or Enanthate) and HCG injections. Interestingly, we have also noted improved https://bank.nauchniestati.ru/steroids-safe/steroid-zur-verbesserten-regeneration-zwischen-den/ compliance with small daily dosing into the subcutaneous tissue, as injections are relatively painless compared to the more traditional intramuscular injections. Daily administration also means that injecting simply becomes a part of your morning routine, much like brushing your teeth. As we can see, more stable levels are reached with smaller differences between the peaks and troughs.
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The importance of SHBG has been discussed in ‘TRT, SHBG & Health – Facts, Questions and Evolution‘. We need to adopt a holistic approach to patient care as both qualitative well-being and quantitative markers can differ widely, between 15 nmol/L and 30 nmol/L, based on the individual. The quantitative level of a particular hormone present in your body at any one time has a direct and indirect effect on numerous physiological processes. To achieve homeostasis, too much is often as bad as too little in what is a very complex mechanism that necessitates fine control for optimum function. With microdosing, we have noted fewer clinical side effects, such as raised haematocrit and elevated Oestradiol which are well recognised with other protocols.